Open AccessSPR-imaging based assays on an oligonucleotide-array to analyze DNA lesions recognition and excision by repair proteins
Author(s) -
Christelle Corne,
Jean-Bernard Fiche,
Valérie Cunin,
Arnaud Buhot,
Julia Fuchs,
R. Calemczuk,
Alain Favier,
Thierry Livache,
Didier Gasparutto
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn126
Subject(s) - oligonucleotide , dna , computational biology , bioanalysis , dna repair , microbiology and biotechnology , biology , chemistry , genetics , chromatography
An original oligonucleotide-array, coupled with SPR-imaging detection, has been developed to study biological interactions between DNA base lesions and DNA repair enzymes. This bioanalytical tool constitutes an efficient screening platform to quantify DNA repair activities and to search for new DNA repair inhibitors.
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