New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex. | Zendy

Hélène Bertrand | Zendy; Sophie Bombard | Zendy; David Monchaud | Zendy; MariePaule TeuladeFichou | Zendy

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New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex.

Author(s) -

Hélène Bertrand,

Sophie Bombard,

David Monchaud,

MariePaule TeuladeFichou

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn083

Subject(s) - g quadruplex , terpyridine , platinum , chemistry , dna , covalent bond , combinatorial chemistry , stereochemistry , ligand (biochemistry) , biochemistry , metal , organic chemistry , catalysis , receptor

Two novel series of platinum(II) complexes have been designed and shown to interact with the human telomeric G-quadruplex-DNA via different binding modes: i- terpyridine-platinum (Pt-tpy) complexes covalently interact with quadruplex-DNA via selective platination of adenine residues of the loops, their interaction being driven by the aromatic surface of the ligand; ii- platinum-quinacridine hybrid (Pt-MPQ) interacts with quadruplex-DNA via a dual noncovalent/covalent binding mode, targeting preferentially guanines constitutive of external G-quartets. Therefore, platinum complexes presented herein constitute potential agents for irreversible trapping of G-quadruplex.DNA.

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