Open AccessA click chemistry approach towards nucleic acid major groove functionalization
Author(s) -
Nicolai K. Andersen,
Lucie Spáčilová,
Mia Jensen,
P. Kocalka,
Frank Jensen,
Poul Nielsen
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn076
Subject(s) - click chemistry , nucleic acid , surface modification , groove (engineering) , chemistry , combinatorial chemistry , biochemistry , materials science , metallurgy
A synthetic strategy towards new aromatic nucleoside derivatives introducing additional aromatic functionality placed in the major groove of a modified DNA duplex is presented. The functionalities are introduced using Click Chemistry conditions and found to increase the overall duplex stability.
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