Single-strand binding protein enhances invasion of a PNA strand to double-stranded DNA | Zendy

Takumi Ishizuka | Zendy; Makoto Komiyama | Zendy

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Single-strand binding protein enhances invasion of a PNA strand to double-stranded DNA

Author(s) -

Takumi Ishizuka,

Makoto Komiyama

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn072

Subject(s) - single strand , dna , peptide nucleic acid , double strand , d loop , coding strand , nucleic acid , double stranded , sense strand , microbiology and biotechnology , biophysics , chemistry , biology , biochemistry , dna damage , rna , polymerase , gene , mitochondrial dna

We show that, in the presence of single-strand binding protein (SSB), one strand of peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA) in sequence-specific manner, as shown in Figure 1. In the absence of SSB, this kind of strand invasion never occurs. This significant enhancement of invasion can be applied to in vivo applications.

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