Open AccessDevelopment of A3 Adenosine Receptor Ligands
Author(s) -
Lak Shin Jeong
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn040
Subject(s) - adenosine , adenosine receptor , antagonism , adenosine a2b receptor , chemistry , receptor , adenosine a3 receptor , pharmacology , agonist , biology , biochemistry
4'-Thioadenosines have been discovered as novel templates for A(3) adenosine ligands. Among these, 4'-thioadenosine-5'-monoalkyluronamides were discovered as novel potent and selective A(3) adenosine receptor agonists, while 4'-thioadenosine-5'-dialkyluronamides and truncated 4'-thioadenosine derivatives exhibited potent and selective antagonism at the A(3) adenosine receptor.
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