A Whole Base-Labile Strategy for RNA Synthesis with 2'-O-acetalester Protections | Zendy

Thomas Lavergne | Zendy; Anthony R. Martin | Zendy; Françoise Debart | Zendy; JeanJacques Vasseur | Zendy

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A Whole Base-Labile Strategy for RNA Synthesis with 2'-O-acetalester Protections

Author(s) -

Thomas Lavergne,

Anthony R. Martin,

Françoise Debart,

JeanJacques Vasseur

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn026

Subject(s) - base (topology) , rna , chemistry , combinatorial chemistry , biochemistry , mathematics , gene , mathematical analysis

The use of base-labile groups for 2'-OH protection is a major challenge for RNA synthesis. A new method with acyloxymethyl groups has been developed. These groups were fully compatible with standard base-labile protections for nucleobases and phosphates and were removed in a short two-step all-base deprotection. Oligoribonucleotides were synthesized efficiently, rapidly and in high purity without chain rupture or isomerisation via this new whole base-labile strategy.

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