Artificial molecular switches made from DNA | Zendy

Eike Friedrichs | Zendy; Angeliki Tsokou | Zendy; Ralf Jungmann | Zendy; Friedrich C. Simmel | Zendy

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Artificial molecular switches made from DNA

Author(s) -

Eike Friedrichs,

Angeliki Tsokou,

Ralf Jungmann,

Friedrich C. Simmel

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn009

Subject(s) - dna , aptamer , nanotechnology , rna , realization (probability) , molecular machine , component (thermodynamics) , chemistry , computational biology , computer science , gene , materials science , biology , physics , genetics , biochemistry , statistics , mathematics , thermodynamics

The unique biochemical and biophysical properties of DNA can be utilized to construct nanoscale machines and switches, among them devices which can stretch and rotate, translocate, or perform computations. Switchable devices based on aptamers can controllably bind or release enzymes, which can be used to control biochemical reactions. DNA can also be used as a component for switchable materials, e.g. for the realization of switchable gels. These might find applications in the controlled release of particles or substances. An exciting possibility lies in the interaction of DNA nanodevices with RNA molecules. For instance, the behavior of DNA nanodevices may be controlled by natural or artificial gene regulatory mechanisms.

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