Open AccessDNA and RNA Quadruplex ligands
Author(s) -
Anne De Cian,
Julien Gros,
Aurore Guédin,
M. Haddi,
Sébastien Lyonnais,
Lionel Guittat,
JeanFrançois Riou,
C Trentesaux,
Barbara Saccà,
Laurent Lacroix,
Patrizia Alberti,
JeanLouis Mergny
Publication year - 2008
Publication title -
nucleic acids symposium series
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrn004
Subject(s) - guanine , nucleic acid , dna , rna , g quadruplex , chemistry , nucleotide , nucleic acid structure , biochemistry , computational biology , stereochemistry , biology , gene
Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes. We explore the binding of a pyridine dicarboxamide derivative to various oligoribo- and oligodeoxyribo-nucleotides.
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