Nucleic acid duplexes with zippers of additional nucleobases and aromatics in minor or major groove | Zendy

Poul Nielsen | Zendy; Khalil I. Shaikh | Zendy; Lise J. Nielsen | Zendy; Nicolai K. Andersen | Zendy; Lucie Spáčilová | Zendy; Henrik Nielsen | Zendy; P. Kocalka | Zendy; Michael Christensen | Zendy

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Nucleic acid duplexes with zippers of additional nucleobases and aromatics in minor or major groove

Author(s) -

Poul Nielsen,

Khalil I. Shaikh,

Lise J. Nielsen,

Nicolai K. Andersen,

Lucie Spáčilová,

Henrik Nielsen,

P. Kocalka,

Michael Christensen

Publication year - 2008

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrn003

Subject(s) - nucleobase , stacking , dna , nucleic acid , chemistry , base pair , groove (engineering) , stereochemistry , cycloaddition , epoxide , biochemistry , organic chemistry , materials science , metallurgy , catalysis

Two series of thymidine derivatives with additional nucleobases/aromatics attached to either the 5'(S)-C- or the 5-position were prepared by epoxide opening and/or "click chemistry" cycloaddition protocols and introduced into DNA duplexes. Interstrand base-base communication in the minor groove and intrastrand stacking interactions in the major groove were detected.

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