Anti-angiogenic activities of nucleosides and nucleotides and their structure-activity relationship | Zendy

Ikuko Tsukamoto | Zendy; Ryoji Konishi | Zendy; Yasuo Kubota | Zendy; M. Tokuda | Zendy; Norikazu Sakakibara | Zendy; Takahiro Maruyama | Zendy

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Anti-angiogenic activities of nucleosides and nucleotides and their structure-activity relationship

Author(s) -

Ikuko Tsukamoto,

Ryoji Konishi,

Yasuo Kubota,

M. Tokuda,

Norikazu Sakakibara,

Takahiro Maruyama

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm219

Subject(s) - potency , nucleotide , umbilical vein , moiety , chemistry , endogeny , structure–activity relationship , biochemistry , stereochemistry , in vitro , gene

The effects of nucleosides and nucleotides on the tube formation of human umbilical vein endothelial cells (HUVEC) were compared. Twenty eight compounds including endogenous species were examined and many of them were revealed to have inhibitory potency. The potency was strengthened significantly when the sugar moiety of ribonucleosides was modified. In case that chlorine was introduced to the 2-position of adenine, the potency also increased. The structure-activity relationship was considered together with the effects on the proliferation of HUVEC.

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