Development of stable DNA microarray platforms suitable for quantitative analysis | Zendy

Nagendra Kumar Kamisetty | Zendy; Seung Pil Pack | Zendy; Mitsuru ogawa | Zendy; Kamakshaiah Charyulu Devarayapalli | Zendy; Yasuko Yoshida | Zendy; Kenneth M. Yamada | Zendy; Tsutomu Kodaki | Zendy; Keisuke Makino | Zendy

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Development of stable DNA microarray platforms suitable for quantitative analysis

Author(s) -

Nagendra Kumar Kamisetty,

Seung Pil Pack,

Mitsuru ogawa,

Kamakshaiah Charyulu Devarayapalli,

Yasuko Yoshida,

Kenneth M. Yamada,

Tsutomu Kodaki,

Keisuke Makino

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm164

Subject(s) - silanization , dna , dna microarray , microarray , linker , computational biology , chemistry , nanotechnology , computer science , biology , materials science , gene , biochemistry , gene expression , organic chemistry , operating system

DNA microarray has become one of the most indispensable tools for genome analysis, medical diagnosis and molecular biological studies. In this study, to make DNA microarray more reliable and efficient, we employed additional silanization modification on aminoalkoxysilane-treated surface. In addition, oxanine was used as a linker of DNA probe, which does not require any chemical activation step in probe immobilization. These strategies were practically convenient in DNA microarray fabrication, and the newly developed system showed enhanced stability for the immobilized DNA probes that could be useful for quantitative analysis.

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