Development of a Specific Fluorescent Probe for 8-Oxoguanosine | Zendy

Syû Ono | Zendy; Zhiqing Li | Zendy; Y. Koga | Zendy; Akira Tsujimoto | Zendy; Osamu Nakagawa | Zendy; Shigeki Sasaki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Development of a Specific Fluorescent Probe for 8-Oxoguanosine

Author(s) -

Syû Ono,

Zhiqing Li,

Y. Koga,

Akira Tsujimoto,

Osamu Nakagawa,

Shigeki Sasaki

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm158

Subject(s) - fluorescence , fluorophore , clamp , guanosine , chemistry , biophysics , biology , biochemistry , optics , physics , clamping , mechanical engineering , engineering

8-Oxoguanosine (8-oxoG) is derived from the oxidation of guanosine (dG) and is known to induce transversion mutations (G:C to T:A) in DNA. We have already reported the fluorescent probe "8-oxoG-clamp", which shows a selective fluorescence quenching phenomenon toward 8-oxoG. In this study, attachment of an additional fluorophore to 8-oxoG-clamp was investigated as a strategy for the detection of 8-oxoG by a fluorescence color change attributed to the 8-oxoG-clamp.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research