Synthesis of naphthyridine-conjugated DNA probes and their application to SNPs typing | Zendy

Akio Kobori | Zendy; Takuto Mori | Zendy; Asako Yamayoshi | Zendy; Akira Murakami | Zendy

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Synthesis of naphthyridine-conjugated DNA probes and their application to SNPs typing

Author(s) -

Akio Kobori,

Takuto Mori,

Asako Yamayoshi,

Akira Murakami

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm155

Subject(s) - typing , dna , computational biology , genetics , biology

We have developed diaminonaphthyridine-conjugated DNA probes (DANP-ODNs), which contain diaminonaphtyridine (DANP) derivatives at 5' end of oligodeoxynucleotides. We here report the synthesis and fluorescence properties of aeDNAP-ODN, ahDANP-ODN, and baeDANP-ODN which contains N-amino ethyl-2,7-diamino-1,8-naphtyridine, N-aminohexyl-2,7-diamino1,8-naphthyridine, and N,N'-bisaminoethyl-2,7-diamino-1,8-naphtyridine, respectively. The emission spectra of DANP-ODNs were measured in the presence of their complementary strand having single nucleotide alteration. The fluorescence intensity at 420 nm of baeDANP-ODN is 12-fold higher in the presence of Callele ODN than that in the presence of A-allele ODN.

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