Open AccessSynthesis of an Artificial Oligonucleotide an Efficient Cycloaddition Reaction
Author(s) -
Tomoko Fujino,
G. Marine,
Eiichi Nakamura
Publication year - 2007
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrm134
Subject(s) - cycloaddition , oligonucleotide , azide , furanose , click chemistry , combinatorial chemistry , nucleobase , triazole , chemistry , elongation , acetylene , organic chemistry , materials science , ring (chemistry) , dna , catalysis , biochemistry , metallurgy , ultimate tensile strength
We developed a new class of artificial oligonucleotides bearing triazole linkers between furanose-like cyclic structures with nucleobase. Elongation reaction of the oligonucleotide was achieved efficiently by [3 + 2] cycloaddition reaction between acetylene and azide.
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