T-loop formation by human telomeric G-quadruplex | Zendy

Yan Xu | Zendy; Hiroyuki Sato | Zendy; Kenichi Shinohara | Zendy; Makoto Komiyama | Zendy; Hiroshi Sugiyama | Zendy

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T-loop formation by human telomeric G-quadruplex

Author(s) -

Yan Xu,

Hiroyuki Sato,

Kenichi Shinohara,

Makoto Komiyama,

Hiroshi Sugiyama

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm122

Subject(s) - telomere , g quadruplex , telomerase , loop (graph theory) , dna , chemistry , biophysics , topology (electrical circuits) , stereochemistry , biology , gene , biochemistry , mathematics , combinatorics

T-loops were a proposed telomere structure and have been speculated to protect telomeres and regulate telomerase. In the current study, we examined the structural and thermodynamic properties of the dimeric G-quadruplex of human telomeric DNA using chemical modifications and CD spectroscopy. We demonstrated that the dimeric G-quadruplex topology induced the T-loop formation in K(+) solution.

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