Development of Novel Oxygen-Independent Photosensitizers | Zendy

Zhenfeng Zhang | Zendy; Kenichi Haruna | Zendy; Takanori Ito | Zendy; Hiroshi Hatta | Zendy; Satoshi Nishimoto | Zendy

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Development of Novel Oxygen-Independent Photosensitizers

Author(s) -

Zhenfeng Zhang,

Kenichi Haruna,

Takanori Ito,

Hiroshi Hatta,

Satoshi Nishimoto

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm115

Subject(s) - chemistry , camptothecin , oxygen , photosensitizer , deoxyguanosine , alkylation , molecule , cleavage (geology) , combinatorial chemistry , photochemistry , dna , biophysics , biochemistry , catalysis , organic chemistry , materials science , biology , fracture (geology) , composite material

We proposed a strategy of photooxidizer-reduction activated alkylator (P-A) hybrid molecule to develop novel oxygen-independent photosensitizers. Two prototypes of such photosensitizers camptothecin-indolequinone (CPT-IQ) and camptothecin-nitrofuryl (CPT-NF) was designed and prepared. A mechanism of photo-induced oxidation and alkylation of 2'-deoxyguanosine by CPT-IQ was investigated. CPT-NF was confirmed to effectively induce DNA cleavage via 365-nm UV irradiation both under normaxia and hypoxia.

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