Radiation-induced one-electron reduction of oligodeoxynucleotides possessing disulfide bond | Zendy

E. Kuraseko | Zendy; Kazuhito Tanabe | Zendy; Satoshi Nishimoto | Zendy

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Radiation-induced one-electron reduction of oligodeoxynucleotides possessing disulfide bond

Author(s) -

E. Kuraseko,

Kazuhito Tanabe,

Satoshi Nishimoto

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm112

Subject(s) - disulfide bond , radiolysis , aqueous solution , chemistry , intermolecular force , photochemistry , electron , solvated electron , one electron reduction , crystallography , molecule , organic chemistry , electrochemistry , biochemistry , physics , quantum mechanics , electrode

Hypoxic X-radiolysis of diluted aqueous solution was performed to generate hydrated electrons that induced one-electron reduction of oligodeoxynucleotides (ODN) possessing a disulfide bond. The disulfide bond was cleaved into thiols, which underwent subsequent reoxidation to produce three forms of disulfide ODNs via intermolecular strand crossing.

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