The reactivity of compounds having cyclopropane ring as the reactive site of drugs with DNA bases | Zendy

Toshiya Okajima | Zendy

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The reactivity of compounds having cyclopropane ring as the reactive site of drugs with DNA bases

Author(s) -

Toshiya Okajima

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm108

Subject(s) - cyclopropane , aziridine , chemistry , sn2 reaction , nucleophile , ring (chemistry) , reactivity (psychology) , stereochemistry , ethylene , ethylene oxide , medicinal chemistry , computational chemistry , organic chemistry , catalysis , medicine , polymer , alternative medicine , pathology , copolymer

Theoretical calculations were performed to study the transition state structures (TSs) and activation energies (deltaE not equal) for S(N)1 and S(N)2 type nucleophilic binding reactions of cyclopropane (3) and its derivatives. The results were compared with those of ethylene oxide (1), aziridine (2), and these derivatives. These parent three-membered ring compounds were chosen as reactive sites of drugs (such as mutagens or carcinogens).

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