Photocontrol of site-selective RNA scission | Zendy

К. Таnака | Zendy; Yoji Yamamoto | Zendy; Akinori Kuzuya | Zendy; Makoto Komiyama | Zendy

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Photocontrol of site-selective RNA scission

Author(s) -

К. Таnака,

Yoji Yamamoto,

Akinori Kuzuya,

Makoto Komiyama

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm103

Subject(s) - azobenzene , phosphodiester bond , bond cleavage , chemistry , rna , acridine , photochemistry , dna , heteroduplex , cleavage (geology) , stereochemistry , materials science , biochemistry , molecule , organic chemistry , catalysis , fracture (geology) , composite material , gene

Novel photoresponsive systems for site-selective RNA scission have been prepared by combining metal ions with DNA bearing an azobenzene adjacent to an acridine. The modified DNA forms a heteroduplex with the substrate RNA, and selectively activates the phosphodiester linkages in front of the acridine, only when the azobenzene is isomerized into cis form by UV irradiation. Trans-azobenzene, on the other hand, effectively suppresses the reaction. As a result, 1.7-2.4-fold acceleration of the cleavage was achieved only with 3 min UV irradiation.

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