Open AccessSequence-specific cleavage of human telomere DNA by G-quadruplex formation
Author(s) -
Yan Xu,
Yasuhisa Hirohata,
Makoto Komiyama
Publication year - 2007
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrm100
Subject(s) - telomere , g quadruplex , dna , cleavage (geology) , computational biology , sequence (biology) , dna sequencing , biology , genetics , paleontology , fracture (geology)
In the current study, we reported that oligonucleotide with EDTA-Fe at 5' end causes a sequence specific break in human telomeric DNA strand by G-quadruplex formation.
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