Gene manipulation of adenovirus vector by artificial restriction DNA cutter | Zendy

Narumi Shigi | Zendy; Kosuke Otani | Zendy; Makoto Komiyama | Zendy

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Gene manipulation of adenovirus vector by artificial restriction DNA cutter

Author(s) -

Narumi Shigi,

Kosuke Otani,

Makoto Komiyama

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm099

Subject(s) - vector (molecular biology) , restriction site , construct (python library) , restriction enzyme , viral vector , genetic enhancement , gene , dna , biology , computational biology , vectors in gene therapy , computer science , artificial intelligence , genetics , recombinant dna , programming language

Adenovirus vector is a useful tool for research in gene expression and regulation as well as gene therapy. However, the size of this vector is too large to construct it by a simple method. In this study, we successfully cleaved specifically at one target site of this large vector by artificial restriction DNA cutter (ARCUT). This result suggests that ARCUT will be the powerful tool for construction of large sized virus vectors.

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