Interaction with and cleavage of DNA by novel phenanthroline polyamine derivative | Zendy

Takeshi Sasagase | Zendy; Takayuki Arai | Zendy; Masayasu Kuwahara | Zendy; Hiroaki Ozaki | Zendy; H. Sawai | Zendy

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Interaction with and cleavage of DNA by novel phenanthroline polyamine derivative

Author(s) -

Takeshi Sasagase,

Takayuki Arai,

Masayasu Kuwahara,

Hiroaki Ozaki,

H. Sawai

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm097

Subject(s) - polyamine , phenanthroline , cleavage (geology) , chemistry , dna , conjugate , combinatorial chemistry , derivative (finance) , metal ions in aqueous solution , plasmid , stereochemistry , biochemistry , metal , biology , crystallography , organic chemistry , paleontology , mathematical analysis , mathematics , fracture (geology) , financial economics , economics

Phenanthroline-polyamine conjugates were synthesized by cross-linking of 1,10-phenanthroline to branched polyamines. The conjugates interacted with DNA strongly, and cleaved plasmid DNA hydrolytically without any metal ions under physiological conditions. The phenanthroline-polyamine conjugates also cleaved linear 30mer DNA at the bulged-out region without metal ions under physiologic conditions.

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