Further stabilization of the double stranded DNA complex by naphthalene diimide derivative having 2,2-dipicolylamine-zinc complex | Zendy

S. Watanabe | Zendy; Keiichi Ohtsuka | Zendy; Shigeori Takenaka | Zendy

Open Access

Further stabilization of the double stranded DNA complex by naphthalene diimide derivative having 2,2-dipicolylamine-zinc complex

Author(s) -

S. Watanabe,

Keiichi Ohtsuka,

Shigeori Takenaka

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm096

Subject(s) - chemistry , diimide , phosphodiester bond , dna , dissociation (chemistry) , derivative (finance) , intercalation (chemistry) , naphthalene , stereochemistry , zinc , crystallography , molecule , inorganic chemistry , organic chemistry , biochemistry , perylene , rna , financial economics , economics , gene

Designed naphthalene diimide derivative having 2,2-dipicolylamine (Dpa), NDI-Dpa, could form a Zn(2+) complex and bind to calf thymus DNA with 10-times higher stabilization than that of NDI-Dpa. The obtained SDS-driven dissociation rate constant was 1.0 s(-1), which is smaller than that of NDI-Dpa. These results suggested that NDI-Dpa-Zn can bind to double stranded DNA through threading intercalation and its complex was stabilized by the interaction of Dpa-Zn parts of NDI-Dpa-Zn and phosphodiester parts of dsDNA.

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