Reversible control of DNA hybridization by photoresponsive ligands | Zendy

Shinnosuke Uno | Zendy; Chikara Dohno | Zendy; Makoto Oku | Zendy; Kazuhiko Nakatani | Zendy

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Reversible control of DNA hybridization by photoresponsive ligands

Author(s) -

Shinnosuke Uno,

Chikara Dohno,

Makoto Oku,

Kazuhiko Nakatani

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm087

Subject(s) - azobenzene , linker , duplex (building) , chromophore , dna , chemistry , photochromism , combinatorial chemistry , biophysics , molecule , photochemistry , biology , biochemistry , computer science , organic chemistry , operating system

Mismatch binding ligands (MBL) can act as a molecular glue which brings two single stranded DNAs (ssDNA) together to form a double stranded DNA (dsDNA). We here demonstrate that photoresponsive MBL possessing a photochromic azobenzene chromophore can control duplex stability reversibly in response to external light stimuli. Synthesis and evaluation of a series of NCDA derivatives reveals significant correlation between the linker structures in MBLs and the molecular glue function.

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