Synthesis of novel fluorescent nucleoside bearing 3aminobenzonitrile as a nucleobase | Zendy

Hiroaki Ozaki | Zendy; T. Setaka | Zendy; Shuhei Tsuchiya | Zendy; Tsuyoshi Kawai | Zendy; Masayasu Kuwahara | Zendy; Hiroaki Sawai | Zendy

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Synthesis of novel fluorescent nucleoside bearing 3aminobenzonitrile as a nucleobase

Author(s) -

Hiroaki Ozaki,

T. Setaka,

Shuhei Tsuchiya,

Tsuyoshi Kawai,

Masayasu Kuwahara,

Hiroaki Sawai

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm069

Subject(s) - fluorescence , nucleoside , nucleobase , chemistry , photochemistry , palladium , nucleoside analogue , quenching (fluorescence) , polarity (international relations) , derivative (finance) , combinatorial chemistry , biophysics , stereochemistry , dna , organic chemistry , biochemistry , catalysis , biology , physics , quantum mechanics , financial economics , economics , cell

Fluorescent nucleoside analogue bearing 3-amiobenzonitrile, which was a small and sensitive fluoresces probe to the microenvironment, was synthesized by a palladium-mediated Heck-type coupling reaction from iodated 3-aminobenzonitrile derivative and protected glycal. The spectroscopic study of the nucleoside analogue indicated that the fluorescence quenching caused in water and the fluorescent maximum was strongly dependent on the polarity of solvents.

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