Nucleoside H-boranophosphonates: Synthesis and properties of a new class of nucleotide analogs | Zendy

Renpei Higashida | Zendy; Takaaki Kawanaka | Zendy; Natsuhisa Oka | Zendy; Takayuki Wada | Zendy

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Nucleoside H-boranophosphonates: Synthesis and properties of a new class of nucleotide analogs

Author(s) -

Renpei Higashida,

Takaaki Kawanaka,

Natsuhisa Oka,

Takayuki Wada

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm067

Subject(s) - nucleoside , nucleotide , condensation , chemistry , nucleic acid , combinatorial chemistry , organic chemistry , condensation reaction , stereochemistry , catalysis , biochemistry , physics , gene , thermodynamics

Nucleoside H-boranophosphonates were synthesized via the condensation reactions of appropriately protected nucleosides with monopyridinium H-boranophosphonate. The condensation reactions gave only the mono-esterified products under the optimized conditions without formation of di-esterified byproducts. Deprotection of the condensation products was achieved under basic conditions to afford the fully-deprotected nucleoside H-boranophosphonates in excellent yields.

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