Food Restriction in Pregnant Mice Can Induce Changes in Histone Modifications and Suppress Gene Expression in Fetus | Zendy

Jafar Sharif | Zendy; Masataka Nakamura | Zendy; Toshiro Ito | Zendy; Yutaka Kimura | Zendy; Teruyuki Nagamune | Zendy; Kohzoh Mitsuya | Zendy; K. Okamura | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Food Restriction in Pregnant Mice Can Induce Changes in Histone Modifications and Suppress Gene Expression in Fetus

Author(s) -

Jafar Sharif,

Masataka Nakamura,

Toshiro Ito,

Yutaka Kimura,

Teruyuki Nagamune,

Kohzoh Mitsuya,

K. Okamura

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm063

Subject(s) - epigenetics , histone , dna methylation , biology , fetus , genomic imprinting , gene , gene expression , regulation of gene expression , psychological repression , histone methylation , transcription (linguistics) , genetics , microbiology and biotechnology , pregnancy , linguistics , philosophy

Biological responses to environmental effects are mediated through epigenetic changes such as chemical modifications of the histone tails and DNA (5-cytosine) methylation. We report that dietary protein restriction in pregnant mice can alter histone modifications in the promoter region of the Igf2 gene and cause a two-fold repression in promoter specific Igf2 transcription in the liver of the fetus. Suppression of Igf2 is accompanied with low birth weight of the pups born to the protein-restricted dams. Our results provide new information about the epigenetic aspects of early life programming and will improve our understanding about the developmental origins of adult diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research