SNPs typing based on the formation of fluorescent signaling DNA aptamers which bind to bile acids | Zendy

T. Kato | Zendy; Saori Kamoto | Zendy; Masumi Hyuga | Zendy; Isao Karube | Zendy

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SNPs typing based on the formation of fluorescent signaling DNA aptamers which bind to bile acids

Author(s) -

T. Kato,

Saori Kamoto,

Masumi Hyuga,

Isao Karube

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm049

Subject(s) - aptamer , single nucleotide polymorphism , nucleotide , dna , typing , computational biology , cholic acid , biology , snp , fluorescence , genetics , chemistry , bile acid , microbiology and biotechnology , gene , biochemistry , genotype , physics , quantum mechanics

A simple and rapid method for the detection of single nucleotide polymorphisms (SNPs) is essential for the development of personalized medicine because SNPs correlate with some diseases and side effects of some drugs. Here we report a new method for the fluorescent detection of single nucleotide mutations that is based on the formation of cholic-acid binding DNA aptamers which form fully matched three-way junctions.

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