Structural and physicochemical features on the metal-mediated base pairs | Zendy

Yoshiyuki Tanaka | Zendy; S. Oda | Zendy; Hiroshi Yamaguchi | Zendy; K. Haruta | Zendy; Takuya Kawamura | Zendy; Yoshinori Kondo | Zendy; T. Uchiyama | Zendy; M Takashi | Zendy; Hideo Takeuchi | Zendy; Hidetaka Torigoe | Zendy; Chojiro Kojima | Zendy; Akira Ono | Zendy

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Structural and physicochemical features on the metal-mediated base pairs

Author(s) -

Yoshiyuki Tanaka,

S. Oda,

Hiroshi Yamaguchi,

K. Haruta,

Takuya Kawamura,

Yoshinori Kondo,

T. Uchiyama,

M Takashi,

Hideo Takeuchi,

Hidetaka Torigoe,

Chojiro Kojima,

Akira Ono

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm038

Subject(s) - base pair , macromolecule , metal , molecule , chemistry , dna , crystallography , duplex (building) , stereochemistry , biochemistry , organic chemistry

The chemical structure of the mercury-mediated T-T pair (T-Hg(I)I-T) was determined with (15)N NMR spectroscopy. In order to determine the chemical structure of the T-Hg(I)I-T pair, (15)N-(15)N J-coupling across a metal center (2JNN) was employed. Notably, this is the first observation of (2)J(NN) in a biological macromolecule (DNA duplex). This pairing mode was found to be a irregular metal ion-binding mode for DNA and RNA molecules, in which imino proton-metal exchange processes are included. Accordingly, (2)J(NN) is highly important for the determination of the chemical structures of metal-mediated base pairs.

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