Open AccessConformationally-2',4'-Locked Aza-ENA and Carbocyclic ribo-Thymidine
Author(s) -
Jyoti Chattopadhyaya
Publication year - 2007
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrm035
Subject(s) - stereochemistry , thymidine , nuclease , chemistry , dna , biochemistry
AONs containing aza-ENA (1), 5-membered (2) and 6-membered (3) carbocyclic analogs of LNA (carbocyclic-LNA-T) and ENA (carbocyclic-ENA-T) are both nuclease resistant and capable of eliciting RNase H response, very similar to that of the native.
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