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Multivalent Catalysts for the Cleavage of Nucleic Acids and their Models
Author(s) -
Florica Manea,
Lucia Pasquato,
Leonard J. Prins,
Paolo Scrimin
Publication year - 2007
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrm034
Subject(s) - nucleic acid , dendrimer , cleavage (geology) , chemistry , catalysis , combinatorial chemistry , nanotechnology , materials science , biochemistry , fracture (geology) , composite material
Multivalent systems, i.e. systems presenting a discrete collection of several functional groups, are well recognized for their ability to increase binding constants. Less explored is their use as catalysts. We present a number of multivalent nanostructures based on self-assembled gold nanoparticles and dendrimers, which are particularly efficient in the cleavage of nucleic acids and their models.

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