Transition State Analogue Inhibitors of N-Ribosyltransferases: New Drugs by Targeting Nucleoside Processing Enzymes. | Zendy

Gary B. Evans | Zendy; Richard H. Furneaux | Zendy; P. M. Kelly | Zendy; Vern L. Schramm | Zendy; Peter C. Tyler | Zendy

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Transition State Analogue Inhibitors of N-Ribosyltransferases: New Drugs by Targeting Nucleoside Processing Enzymes.

Author(s) -

Gary B. Evans,

Richard H. Furneaux,

P. M. Kelly,

Vern L. Schramm,

Peter C. Tyler

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm032

Subject(s) - enzyme , transition state analog , nucleoside , drug , pharmacology , nucleoside analogue , chemistry , biochemistry , biology , active site

The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.

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