The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation | Zendy

Vladimir Gubala | Zendy; María del C. Rivera-Sánchez | Zendy; Gerard Hobley | Zendy; José M. Rivera | Zendy

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The impact of 8-aryl-and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation

Author(s) -

Vladimir Gubala,

María del C. Rivera-Sánchez,

Gerard Hobley,

José M. Rivera

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm020

Subject(s) - deoxyguanosine , g quadruplex , guanine , oligonucleotide , aryl , chemistry , combinatorial chemistry , stereochemistry , dna , biochemistry , organic chemistry , nucleotide , alkyl , gene

Guanine and G-rich oligonucleotides are known to self-assemble in the presence of a variety of cations to form higher ordered structures known as Gquadruplexes. We have synthesized a library of 8-aryl/heteroaryl-2'-deoxyguanosine derivatives (8ArGs) that are also able to self-assemble into quadruplex structures. We demonstrate that the properties of such quadruplexes can be modulated by the nature of the groups attached to the guanine base. These supramolecules are potentially useful in the development of self-assembled nanodevices.

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