Open AccessA new concept in double duplex DNA invasion by chiral PNAs which simultaneously depress PNA-PNA and improve PNA-DNA duplex stability.
Author(s) -
Stefano Sforza,
Tullia Tedeschi,
Roberto Corradini,
Rosangela Marchelli
Publication year - 2007
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrm010
Subject(s) - duplex (building) , dna , chemistry , biophysics , combinatorial chemistry , biology , biochemistry
By using suitably designed chiral, lysine-based PNAs (chPNAs), the stability of complementary chPNAchPNA duplexes can be depressed, maintaining or improving at the same time the stability of the corresponding PNA-DNA duplexes. This approach could be used in order to develop chPNAs able to perform double duplex DNA invasion.
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