Construction of novel dye aggregates based on "comb-type" sequence | Zendy

Hiromu Kashida | Zendy; Tomoyuki Fujii | Zendy; Hiroyuki Asanuma | Zendy

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Construction of novel dye aggregates based on "comb-type" sequence

Author(s) -

Hiromu Kashida,

Tomoyuki Fujii,

Hiroyuki Asanuma

Publication year - 2007

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrm006

Subject(s) - stacking , intermolecular force , duplex (building) , thermal stability , molecule , sequence (biology) , exciton , materials science , crystallography , chemistry , dna , organic chemistry , biochemistry , physics , quantum mechanics

Novel dye aggregates ("comb-type" aggregates) was prepared by hybridizing modified oligodeoxyribo-nucleotides (ODNs), in which dyes were introduced consecutively. From NMR structural analysis, dye molecules were intercalated between base pairs and stacked in anti-parallel manner. When ODNs containing three Methyl Red moieties were hybridized, strong exciton coupling was observed. In addition, thermal stability of duplex was substantially enhanced due to the intermolecular stacking.

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