Recognition of DNA with assembly of minor groove binders mediated by metal complexation | Zendy

Tomonobu Kataoka | Zendy; Mikimasa Tanada | Zendy; Ippei Onishi | Zendy; Shigeki Sasaki | Zendy

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Recognition of DNA with assembly of minor groove binders mediated by metal complexation

Author(s) -

Tomonobu Kataoka,

Mikimasa Tanada,

Ippei Onishi,

Shigeki Sasaki

Publication year - 2006

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/nrl080

Subject(s) - linker , dna , ligand (biochemistry) , chemistry , minor groove , molecule , groove (engineering) , bipyridine , crystallography , stereochemistry , materials science , biochemistry , crystal structure , receptor , organic chemistry , computer science , metallurgy , operating system

Genome-targeting molecules would have broad application as probes in genomic study. We recently developed the ligands (Bpy-H) connecting the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It was shown that L-Bpy-H with a long linker exhibited Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a ratio of 1:2:1 DNA-ligand-Cu(2+). Binding selectivity depends on the distance between the two A(3)T(3) sites of DNA. In contrast, S-Bpy-H having a short linker tended to form 1:2:2 DNA-ligand-Cu(2+) complex.

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