Open AccessChemical synthesis of RNA including 5-taurinomethyluridine
Author(s) -
Toshihiko Ogata,
Takeshi Wada
Publication year - 2006
Publication title -
nucleic acids symposium series
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/nrl005
Subject(s) - rna , computational biology , chemistry , biology , biochemistry , gene
Recently, a novel base-modified uridine derivative, 5-taurinomethyluridine (taum(5)U) was discovered from bovine and human mitochondrial tRNAs, and this modified ribonucleoside was found to existed at the first position of the anti-codon. We report efficient reactions for the synthesis of RNA oligomers including this base-modified ribonucleotide.
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