DNA nanowire sensitive to the surrounding condition | Zendy

Daisuke Miyoshi | Zendy; Zhongming Wang | Zendy; Hisae Karimata | Zendy; Naoki Sugimoto | Zendy

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DNA nanowire sensitive to the surrounding condition

Author(s) -

Daisuke Miyoshi,

Zhongming Wang,

Hisae Karimata,

Naoki Sugimoto

Publication year - 2005

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/49.1.43

Subject(s) - antiparallel (mathematics) , dna , supramolecular chemistry , metal ions in aqueous solution , thymine , ion , g quadruplex , nanowire , materials science , crystallography , nanotechnology , chemistry , crystal structure , biochemistry , organic chemistry , physics , quantum mechanics , magnetic field

We designed and synthesized an artificial DNA that undergoes a structural transition induced by metal ions. A 2, 2'-bipyridine unit was incorporated into the main chain of d(G4T4G4) instead of thymine. Structural analyses of the artificial DNA with and without metal ions demonstrated that micromolar concentrations of metal ions can induce a structural transition of antiparallel G-quadruplex to a G-wire, which shows the DNA is promising as a controllable and switchable supramolecular device.

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