Inhibiting transcription of chromosomal DNA using antigene RNAs | Zendy

Bethany A. Janowski | Zendy; David R. Corey | Zendy

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Inhibiting transcription of chromosomal DNA using antigene RNAs

Author(s) -

Bethany A. Janowski,

David R. Corey

Publication year - 2005

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/49.1.367

Subject(s) - transcription (linguistics) , biology , dna , nucleic acid , gene , rna , gene silencing , genetics , computational biology , microbiology and biotechnology , philosophy , linguistics

Transcription start sites are critical switches for converting recognition of chromosomal DNA into synthesis of RNA. We report that antigene peptide nucleic acid (agPNA) oligomers or antigene RNA (agRNA) duplexes can target transcription start sites and block gene expression. Our data suggest that chromosomal DNA within cells is readily accessible to recognition by synthetic agents. agPNAs and agRNAs will be useful tools for silencing gene expression and will provide insights into natural mechanisms for controlling transcription.

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