Open AccessDesign, synthesis and evaluation of oligomer conjugated MGBpolyamide-nucleoside hybrid as a novel gene expression control compound
Author(s) -
Etsuko Kawashima,
Yusuke Ohba,
Yusuke Terui,
Kazuo Kamaike
Publication year - 2005
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/49.1.327
Subject(s) - conjugated system , minor groove , oligomer , dna , gene expression , nucleoside , gene , chemistry , combinatorial chemistry , deoxyguanosine , stereochemistry , biochemistry , organic chemistry , polymer
DNA oligomers conjugated pyrrolepolyamide (minor groove binder)-deoxyguanosine hybrid were synthesized as novel gene expression control compounds. From T(m) values and CD spectral analysis, it was found that oligomers conjugated hybrid possess high recognition ability and very high binding ability for the DNA that includes pyrrolepolyamide match site.
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