Open AccessSynthesis and biological activity of 4″,6″-unsaturated cyclic ADP-carbocyclic-ribose
Author(s) -
Takashi Kudoh,
Takashi Murayama,
Akira Matsuda,
Satoshi Shuto
Publication year - 2005
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/49.1.25
Subject(s) - cyclic adp ribose , chemistry , stereochemistry , ribose , biochemistry , biology , genetics , enzyme , cd38 , stem cell , cd34
4'',6''-Unsaturated cyclic ADP-carbocyclic-ribose (3) was designed as a novel stale mimic of cyclic ADP-ribose, an intracellular Ca2+-mobilizing second messenger, based on the previous SAR studies, and was successfully synthesized.
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