Open AccessAsymmetric cooperativity in tandem hybridization of the DNA conjugates bearing chiral metal complexes
Author(s) -
Toshihiro Ihara,
Yusuke Kitamura,
K. Okada,
Masato Tazaki,
Akinori Jyo
Publication year - 2005
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/49.1.229
Subject(s) - cooperativity , tandem , conjugate , chemistry , oligonucleotide , phenazine , enantiomer , stereochemistry , dna , combinatorial chemistry , crystallography , biochemistry , materials science , mathematical analysis , mathematics , composite material
Each of the enantiomers of [Ru(phen)2(dppz)]2+ (phen = 1,10-phenanthroline, dppz = dipyrido[3,2-a:2',3'-c]phenazine) complex was attached to the 5' end of the short oligonucleotide to form a pair of the conjugates. The delta-isomer of them showed a high cooperativity in tandem hybridization to the repetitive sequence, while the lambda-isomer did not.
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