Schiff base-mediated base pairing | Zendy

Chikara Dohno | Zendy; Akimitsu Okamoto | Zendy; Isao Saito | Zendy

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Schiff base-mediated base pairing

Author(s) -

Chikara Dohno,

Akimitsu Okamoto,

Isao Saito

Publication year - 2005

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/49.1.185

Subject(s) - schiff base , covalent bond , duplex (building) , pairing , chemistry , base pair , base (topology) , thermal stability , dna , polymer chemistry , organic chemistry , biochemistry , physics , mathematical analysis , superconductivity , mathematics , quantum mechanics

We here present a novel covalently linked base pair via Schiff base formation between 5-formyluracil (fU) and 5-aminocytosine (AmC). The formation of Schiff base remarkably increases thermal stability of the duplex DNA, whereas it completely dissociates upon heating at 90 degrees C. Neither AmC nor fU produces covalent linkage with other natural bases, and thus the pairing ability of AmC and fU is very specific.

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