Open AccessCharacterization of Na+-montmorillonite-catalyzed reaction of racemic ribonucleotides
Author(s) -
Hidehito Urata,
Mami Fujimori,
Chie Aono,
Emi Hrada,
Tomoko Matsumoto,
Tomomi Yamakawa,
Masao Akagi
Publication year - 2005
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/49.1.115
Subject(s) - montmorillonite , catalysis , chemistry , yield (engineering) , dimer , selectivity , reaction conditions , organic chemistry , medicinal chemistry , materials science , metallurgy
We have reported that the oligomerization of racemic mononucleotides catalyzed by montmorillonite clay proceeds efficiently and gives up to 8-mer. Here, we attempted to identify the dimer products to show the characteristics of the racemic reaction. The results suggested that homochiral pApAs are formed in somewhat higher yield than heterochiral pApAs. Therefore, the oligomerization of racemic mononucleotides catalyzed by montmorillonite shows the homochiral selectivity.
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