Fluorescent probe for the detection of DNA conformational transition | Zendy

Yuta Ochi | Zendy

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Fluorescent probe for the detection of DNA conformational transition

Author(s) -

Yuta Ochi

Publication year - 2004

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/48.1.73

Subject(s) - fluorescence , excimer , pyrene , chemistry , monomer , transition (genetics) , conformational change , dna , photochemistry , crystallography , stereochemistry , polymer , biochemistry , organic chemistry , physics , gene , quantum mechanics

Two pyrene-labeled bases, (py)C and (8py)G, have been synthesized and incorporated into d(CG)n. In the CD spectra, structural transition of a modified oligodeoxynucleotide (ODN-Py) from B-form to Z-form has been observed under different salt concentrations. The conformational transition of ODN-Py was monitored by the change of emission wavelengths based on exciplex and monomer fluorescence of (py)C and (8py)G.

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