Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity | Zendy

Mariko Aso | Zendy; Mitsuhiro Fukuda | Zendy; Kazuteru Usui | Zendy; Hiroshi Suemune | Zendy

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Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity

Author(s) -

Mariko Aso,

Mitsuhiro Fukuda,

Kazuteru Usui,

Hiroshi Suemune

Publication year - 2004

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/48.1.59

Subject(s) - oligonucleotide , duplex (building) , reactivity (psychology) , chemistry , thymidine , lewis acids and bases , ap site , catalysis , combinatorial chemistry , dna , biochemistry , dna damage , medicine , alternative medicine , pathology

We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

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