Open AccessAnalysis of DNA damage generated by high-energy particles
Author(s) -
Hiroaki Terato
Publication year - 2004
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/48.1.145
Subject(s) - ionizing radiation , linear energy transfer , dna , plasmid , dna damage , irradiation , microbiology and biotechnology , biology , genetics , biophysics , chemistry , physics , nuclear physics
Ionizing radiation generates isolated and localized multiple (i.e., clustered) lesions in DNA, and the latter is believed to be primarily responsible for deleterious biological consequences such as cell killing and mutations. In the present study, we irradiated plasmid and lambda DNA by ionizing radiations with different linear energy transfer (LET) values, and compared the yields of isolated and clustered DNA lesions.
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