Open AccessTheoretical study about remarkable stability of guanine tetramer
Author(s) -
Shigeru Kawahara
Publication year - 2004
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/48.1.133
Subject(s) - tetramer , guanine , dimer , chemistry , hydrogen bond , stacking , crystallography , computational chemistry , molecule , nucleotide , organic chemistry , biochemistry , enzyme , gene
The cyclic guanine tetramer (G-quartet) formation was theoretically studied. Total hydrogen bond energy in a G-quartet was large (-70.89 kcal/mol). though the hydrogen bond energy in Hoogsteen type guanine dimer was small (-11.26 kcal/mol). A large attractive interaction (-57.84 kcal/mol) was observed for stacking interaction. The hydration effect should be considered to explain the selectivity of metal incorporation into the G-quartet.
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