Open AccessChemical and biological consequences of locking the conformation of nucleosides at the two antipodal extremes of the pseudorotational cycle
Author(s) -
V.E. Márquez
Publication year - 2004
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/48.1.11
Subject(s) - antipodal point , chemistry , enzyme , stereochemistry , biochemistry , mathematics , geometry
It is shown that in spite of the low energy barrier for the North (N)/South (S) equilibrium in nucleosides, enzymes show measurable differences in binding and/or catalytic activity between the two antipodal conformations.
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