Open AccessEvaluation of nucleotide derivatives and sugar nucleotide analogs as inhibitors of glycosyltransferases
Author(s) -
Kazuoki Osumi,
N. Kawauchi,
Aidan Lu,
Ole Hindsgaul,
Monica M. Palcic
Publication year - 2000
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/44.1.89
Subject(s) - glycosyltransferase , nucleotide , uridine , nucleotide sugar , biochemistry , nucleoside , chemistry , sugar , uridine diphosphate , uridine diphosphate glucose , enzyme , rna , gene
The inhibition of glycosyltransferases was studied using uridine monophosphate derivatives and uridine diphosphate sugar analogs. Modification in the nucleoside portion caused selective inhibition of glycosyltransferases.
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